核心观点：
1，Most missense disease mutations appear not to impair protein folding or stability
,2，Interaction profiling helps distinguish disease mutations from non-disease var...
核心观点：
1，Most missense disease mutations appear not to impair protein folding or stability
,2，Interaction profiling helps distinguish disease mutations from non-disease variants,
3，Distinct interaction perturbations underlie distinct disease phenotypes
4，Integrative interaction networks enhance genotype-to-phenotype understanding
Reference: Sahni, Nidhi, et al. "Widespread macromolecular interaction perturbations in human genetic disorders." Cell 161.3 (2015): 647-660.
